![]() In general, animal studies indicate that chelated minerals are absorbed more effectively ( 9, 10). ![]() Meanwhile, a study in pregnant women with iron deficiency found no significant difference in blood iron levels when comparing chelated iron (ferrous bisglycinate) with regular iron (ferrous sulfate) ( 8). Yet, not all studies give the same results.Ī study in 23 postmenopausal women showed that 1,000 mg of calcium carbonate (non-chelated) was more rapidly absorbed and raised blood calcium levels more effectively than the same amount of calcium citrate (chelated) ( 7). This is important for people at risk of excess mineral intake, such as iron overload.įor example, in a study in 300 infants, giving 0.34 mg per pound of body weight (0.75 mg per kg) of iron bisglycinate (chelated) daily raised blood iron levels to levels similar to those caused by 4 times that amount of iron sulfate (non-chelated) ( 6). What’s more, some research suggests that taking chelated minerals may reduce the total amount you need to consume to reach healthy blood levels. Similarly, a study in 30 adults noted that magnesium glycerophosphate (chelated) raised blood magnesium levels significantly more than magnesium oxide (non-chelated) ( 5). Several studies have compared the absorption of the two.įor example, a study in 15 adults found that chelated zinc (as zinc citrate and zinc gluconate) was absorbed around 11% more effectively than non-chelated zinc (as zinc oxide) ( 4). Most mineral supplements are available in chelated form.ĭo chelated minerals have better absorption?Ĭhelated minerals are often touted as having better absorption than non-chelated ones. Picolinic acid: used to make chromium picolinate, manganese picolinate, and moreĬhelated minerals are usually joined to either organic acids or amino acids.Fumaric acid: used to make iron (ferrous) fumarate.Gluconic acid: used to make iron gluconate, zinc gluconate, and more.Orotic acid: used to make magnesium orotate, lithium orotate, and more.Citric acid: used to make chromium citrate, magnesium citrate, and more.Acetic acid: used to make zinc acetate, calcium acetate, and more.Organic acids used to make mineral chelates include: Glycine: used to make magnesium glycinate.Monomethionine: used to make zinc monomethionine.Methionine: used to make copper methionine, zinc methionine, and more.Aspartic acid: used to make zinc aspartate, magnesium aspartate, and more.These amino acids are commonly used to make mineral chelates: They’re typically made using an amino or organic acid. doi:10.Most minerals are available in chelated form. Chromium supplementation in human health, metabolic syndrome, and diabetes. The Nutritional Biochemistry of Chromium (III). Chromium supplements in health and disease. A meta-analysis of the effect of chromium supplementation on anthropometric indices of subjects with overweight or obesity. Tsang C, Taghizadeh M, Aghabagheri E, Asemi Z, Jafarnejad S. Effects of chromium picolinate on food intake and satiety. A double-blind, placebo-controlled, exploratory trial of chromium picolinate in atypical depression: Effect on carbohydrate craving. doi:10.1253/circj.CJ-17-0032ĭocherty JP, Sack DA, Roffman M, Finch M, Komorowski JR. Chromium exposure and risk of cardiovascular disease in high cardiovascular risk subjects - nested case-control study in the Prevention With Mediterranean Diet (PREDIMED) Study. Gutiérrez-Bedmar M, Martínez-González MÁ, Muñoz-Bravo C, et al. Effect of chromium supplementation on glucose metabolism and lipids: A systematic review of randomized controlled trials. Chromium picolinate positively influences the glucose transporter system via affecting cholesterol homeostasis in adipocytes cultured under hyperglycemic diabetic conditions. Pattar GR, Tackett L, Liu P, Elmendorf JS. Beneficial effect of chromium supplementation on glucose, HbA1C and lipid variables in individuals with newly onset type-2 diabetes. Sharma S, Agrawal RP, Choudhary M, Jain S, Goyal S, Agarwal V. Comparison of chromium and iron distribution in serum and urine among healthy people and prediabetes and diabetes patients.
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